Dear Valerie ,
The concerns you convey concerning altering neurons in the sections of the brain not related to perception are not unfounded and testing is being done to heighten areas of the brain that can be encouraged to secrete small doses of hormones that can satisfy the requirements of a sexual imbue during interface ...however functions of certain glands responsible for arousal and "a sense of intimacy" if tinkered with can cause some quite horrific alterations in physiology concerning all aspects of a humans' biological self regulating systems. While we have moved forward conducting
tests that deal almost exclusively with gland based alterations in Humans who have been endowed with Merge we are concerned about the usual "hit or miss" inevitabilities* of re - sequencing these specific avenues of Mind Augment as there is a delicate balance between dopamine for instance causing a feeling of pleasure and causing hyper-aggression. Early on you informed me that Proxy Cyber must take risks and pride itself on an "Anything Goes" outlook considering Human Testing, I too feel we must not always weigh the risks when progress has always relied on it's fair share of hazards. As some of these tests hint at risks we will not discuss please read carefully my list of subjects who you have mentioned might be in "our best interest to phase out of The Program" as I myself have ideas on this particular subject .
Thank You,
Tru Christie.
Frequency of Dopamine Concentration Transients Increases in Dorsal and Ventral Striatum of Male Rats during Introduction of Conspecifics
Donita L. Robinson, Michael L. A. V. Heien, and R. Mark Wightman Department of Chemistry, Neuroscience Center, and Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599-3290
Transient, elevated concentrations of extracellular dopamine were characterized in the dorsal and ventral striatum of male rats during solitude, brief interaction with a conspecific, and copulation. Conspecific rats were systematically presented to male rats and allowed to interact for 30 sec; the males were kept in solitude between each presentation. During these episodes, 125 dopamine concentration transients from 17 rats were detected with fast-scan cyclic voltammetry at carbonfiber microelectrodes (peak amplitude, 210 10 nM; duration, 530 20 msec). The frequency of dopamine transients increased sixfold during conspecific episodes compared with solitude. However, the phasic dopamine activity habituated on the second presentation of the conspecifics. When males were allowed to copulate with receptive females, additional dopamine transients were observed at frequencies 20% of those during the previous interaction episodes. A subset of these transients immediately preceded intromission. Overall, phasic
dopamine activity appeared to be associated with input from multiple sensory modalities and was followed by a variety of approach and appetitive behaviors, consistent with electrophysiological observations of dopaminergic neuron burst-firing. In summary, (1) dopamine concentration transients occur in awake rats during solitude, in the absence of overt external cues; (2) dopamine transients are significantly more frequent in the presence of a conspecific, although this effect habituates; and (3) dopamine transients are less frequent during copulation than during brief conspecific episodes. These results establish for the first time that transient dopamine fluctuations occur throughout the dorsal and ventral striatum and demonstrate that they are more frequent with salient stimuli that elicit a response behavior.
*
The concerns you convey concerning altering neurons in the sections of the brain not related to perception are not unfounded and testing is being done to heighten areas of the brain that can be encouraged to secrete small doses of hormones that can satisfy the requirements of a sexual imbue during interface ...however functions of certain glands responsible for arousal and "a sense of intimacy" if tinkered with can cause some quite horrific alterations in physiology concerning all aspects of a humans' biological self regulating systems. While we have moved forward conducting
tests that deal almost exclusively with gland based alterations in Humans who have been endowed with Merge we are concerned about the usual "hit or miss" inevitabilities* of re - sequencing these specific avenues of Mind Augment as there is a delicate balance between dopamine for instance causing a feeling of pleasure and causing hyper-aggression. Early on you informed me that Proxy Cyber must take risks and pride itself on an "Anything Goes" outlook considering Human Testing, I too feel we must not always weigh the risks when progress has always relied on it's fair share of hazards. As some of these tests hint at risks we will not discuss please read carefully my list of subjects who you have mentioned might be in "our best interest to phase out of The Program" as I myself have ideas on this particular subject .
Thank You,
Tru Christie.
Frequency of Dopamine Concentration Transients Increases in Dorsal and Ventral Striatum of Male Rats during Introduction of Conspecifics
Donita L. Robinson, Michael L. A. V. Heien, and R. Mark Wightman Department of Chemistry, Neuroscience Center, and Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599-3290
Transient, elevated concentrations of extracellular dopamine were characterized in the dorsal and ventral striatum of male rats during solitude, brief interaction with a conspecific, and copulation. Conspecific rats were systematically presented to male rats and allowed to interact for 30 sec; the males were kept in solitude between each presentation. During these episodes, 125 dopamine concentration transients from 17 rats were detected with fast-scan cyclic voltammetry at carbonfiber microelectrodes (peak amplitude, 210 10 nM; duration, 530 20 msec). The frequency of dopamine transients increased sixfold during conspecific episodes compared with solitude. However, the phasic dopamine activity habituated on the second presentation of the conspecifics. When males were allowed to copulate with receptive females, additional dopamine transients were observed at frequencies 20% of those during the previous interaction episodes. A subset of these transients immediately preceded intromission. Overall, phasic
dopamine activity appeared to be associated with input from multiple sensory modalities and was followed by a variety of approach and appetitive behaviors, consistent with electrophysiological observations of dopaminergic neuron burst-firing. In summary, (1) dopamine concentration transients occur in awake rats during solitude, in the absence of overt external cues; (2) dopamine transients are significantly more frequent in the presence of a conspecific, although this effect habituates; and (3) dopamine transients are less frequent during copulation than during brief conspecific episodes. These results establish for the first time that transient dopamine fluctuations occur throughout the dorsal and ventral striatum and demonstrate that they are more frequent with salient stimuli that elicit a response behavior.
*
Acromegaly
- Acromegaly is a syndrome that results when the anterior pituitary gland produces excess growth hormone after epiphyseal plate closure at puberty. A number of disorders may increase the pituitary's GH output, although most commonly it involves a tumor called pituitary adenoma, derived from a distinct type of cell.
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