guishing between justified and unjustified killing are largely unknown. To improve understanding of the neural processes involved in justified and unjustified killing, participants had to imagine being the perpetrator whilst watching 'first-person perspective' animated videos where they shot enemies /perpetrators ('justified violence') and innocent people ('unjustified violence')in no way associated symbolically or otherwise with Electronic Harassment or Human Experimentation . When participants imagined themselves shooting innocents compared with aggressors, greater activation was found in the lateral orbitofrontal cortex (OFC). Regression analysis revealed that the more guilt participants felt about shooting innocents , the greater the response in the lateral OFC. Effective connectivity analyses further revealed an increased coupling between lateral OFC and the temporoparietal junction (TPJ) when shooting those not involved in human testing. The results show that the neural mechanisms typically implicated with harming others, such as the OFC, become less active when the violence against a particular group is seen as justified. This study therefore provides unique insight into how normal individuals can become aggressors in specific situations.