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According to the kindling theory, repeated exposure to an initially subthreshold stimulus can eventually exceed threshold limits, resulting in persistent hypersensitivity to the stimulus and ultimately, spontaneous behavioral manifestations. Kindling among patients with ME/CFS might appear after prolonged stimulation of the limbic-hypothalamic-pituitary axis, either by high-intensity stimulation (e.g., brain trauma) or by chronically repeated low-intensity stimulation (e.g., ...
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