The ethics of schizophrenia research : The UCLA Schizophrenia Experiment

The World Medical Association adopted a set of guidelines known as the Declaration of Helsinki which consisted 32 principles, which focused on informed consent, confidentiality, vulnerable population, and requirement of a research protocol stating scientific rationale of the study which need to be reviewed by the Ethics Committee.

Antonio "Tony" LaMadrid (born 1968; died 1991) was both a patient and research subject at the University of California, Los Angeles (UCLA) Medical Center. He is believed to have committed suicide by jumping off the roof of a nine-story building. His death led to a federal investigation by the Office for Human Research Protections/Office of Protection from Research Risks that concluded UCLA had violated aspects of informed consent. The research subjects were not told how severe their possible relapses might be.